|
KMID : 0377619750290010041
|
|
Korean Jungang Medical Journal
1975 Volume.29 No. 1 p.41 ~ p.49
|
|
|
Antimicrobial Susceptibility and Transferable Resistance of Salmonella Typhi
|
|
|
|
|
Abstract
|
|
|
In order to know the yearly variation of antimicrobial susceptibility of Salmonella typhi and to investigate the transferability of resistance by conjugation, 594 str￢ains of S. typhi isolated mainly in Taegu area during the period from 1971 through 1974 were subjected for the study. Antimicrobial susceptibility was tested by agar dilution method and the transfer of resistance was studied with Escherichia coli ML 1410 as recipient.
Most strains were susceptible to chloramphenicol (CM), tetracycline (TC) and kanamycin (KM) with minimum inhibitory concentration (MIC) of 3.1 ug/ml or -less, and highly susceplible to ampicillin (AP) and trimethoprim-sulfamethoxazole compound (TMP-SMZ, i : 20) with MIC of 1.6pg/ml or less. ´They were slightly resistant to streptomycin (SM) and sulfisomidine (SA) with MIC of 25,ug/ml or less.
No marked difference in the antimicrobial spectrum of test strains was noted among strains isolated in 1971 through 1974, only with a slight tendency that strains isolated in 1974 was slightly less susceptible to SM and TMP-SMZ than. those isolated in 1971 through 1973.
Small numbers of strains highly resistant to CM, TC, SM, and SA, and other agents were isolated during the years of 1972 through 1974. The resistance of these, strains can be transferred to E. coli ML 1410 by conjugation, but the resistance to polymyxin B and colistin was not transferred. The resistance was transferred at 25 C more easily than at 37 C.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|